CoolSculpting works by taking advantage of the fact that fat cells are more sensitive to cold than the other cells around them. This basic scientific fact was first discovered in 1970 by doctors observing children who sucked on popsicles for hours, and ended up having first soreness, and later dimples, caused by loss of fat cells! Fast forward about 20 years, and Harvard scientists revisited this fact, and realized that they could turn this science into a system for aesthetic sculpting of fatty bulges. The key was to find the ‘sweet spot’ of time and temperature, which would kill some fat cells but not damage surrounding structures such as skin. They called the public company that makes the systems Zeltiq. The proof of the success of this concept and treatment: Zeltiq was bought out by Allergan in 2016 for whopping 2.5 billion! This was the largest sale of a single medical device company in history.
Fodor is more enthusiastic about the LipoSonix technology. "I am very optimistic," he says." I love the results," he says citing as much as a 7-centimeter reduction in waist circumference seen in clinical trials conducted in Mexico. This technology, which uses high-intensity ultrasound waves, beamed about an inch under the skin to break up fatty tissue, has been studied in both pig models and in 33 people in Mexico, he says. The company has applied for FDA status to begin preclinical studies in the U.S. and expects such trials to begin in 2007.
Fat-dissolving and skin-tightening procedures for body contouring that are less invasive can seem oh-so-appealing when weighed against other options, such as liposuction. Some of the latest innovations include mesotherapy (lipodissolve), which involves the injection of various cocktails into the skin to dissolve fat, Thermage (also known as Thermacool or Thermalift), which uses radiofrequency to tighten facial skin for a "nonsurgical" face-lift, and LipoSonix, which uses high-intensity ultrasound to target and destroy fat cells.
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The most commonly known treatment is liposuction, a surgical procedure with inherent risks that many patients wish to avoid. Now, less invasive energy-based alternatives are available, including energy-assisted liposuction, which is usually gentler in comparison to regular liposuction. Recently, completely non-invasive treatments are showing up in the market but results are less predictable and less impressive.
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A typical CoolSculpting procedure in the U.S. can cost anywhere from $1,000-$4,000. Although the fat cells destroyed by cryolosis are gone permanently, it doesn’t mean a patient cannot regain the weight. Regular diet and exercise should always be a part of a healthy lifestyle. Also, body sculpting is not pain free. Many patients who claim to have a “high pain tolerance” report intense soreness, swelling, bruising, or tenderness both during the procedure and up to weeks afterward. Always, always consult your doctor before trying procedures like selective cryolosis.